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. 2019 Dec 9;130(1):466–479. doi: 10.1172/JCI124332

Figure 3. Antitumor effects of vancomycin plus RT combination treatment are IFN-γ dependent.

Figure 3

(A) Ifng mRNA expression levels in B16-OVA primary tumors collected at 5 days after radiation (21 Gy). (B) ELISA analysis of IFN-γ protein expression levels in tumor lysates 5 days after radiation (21 Gy). (C) Intracellular IFN-γ expression in infiltrating T cells after overnight Kb-OVA peptide stimulation. Mean ± SEM are shown. Statistical significance was assessed by Tukey’s test. (D) The antitumor effects of vancomycin+RT combination treatment are lost in Ifng-KO mice. n = 5 to 10 mice per group. Mean ± SEM are shown. Statistical significance was assessed by 2-way ANOVA. Data are representative of at least 2 independent experiments. *P < 0.05, **P < 0.01.