Figure 3. Cross-dressed host DCs are sufficient for acute islet allograft rejection by effector CD8⁺ T cells.

B6.Act-mOVA (B6.OVA) islets were transplanted to diabetic B6 bone marrow chimeras that had received either a B6.H-2K^b–/– (n = 7) or B6.H-2K^b–/–.CD11c-DTR (n = 5) bone marrow transplant. 1 × 10⁵ OT-I effectors were transferred 7 days after transplantation. DT (5 ng/g) was administered every other day starting on the day of transplantation to both mouse groups. Allografts were deemed rejected when blood glucose level exceeded 300 mg/dl for 3 consecutive days. Mice that died with normal glucose levels before termination of experiment (day 72) were censored and are shown as white circles on the survival line. **P < 0.01, log-rank test.