Table 2.
Aortic root diameter
| Placebo | Irbesartan | Difference (95% CI) | p value | ||
|---|---|---|---|---|---|
| Change in aortic root systolic diameter, mm per year, mean (95% CI) | 0·74 (0·60 to 0·89) | 0·53 (0·39 to 0·67) | −0·22 (−0·41 to −0·02) | 0·030 | |
| Aortic root diameter, mm | |||||
| Baseline, mean (SD), n | 34·4 (5·8), 88 | 34·4 (5·5), 104 | .. | .. | |
| 1 year, mean (95% CI), n | 35·3 (34·4 to 36·1), 85 | 34·5 (33·6 to 35·3), 94 | −0·82 (−1·33 to −0·30) | 0·0017 | |
| 2 years, mean (95% CI), n | 35·9 (35·0 to 36·8), 77 | 35·2 (34·3 to 36·0), 85 | −0·75 (−1·41 to −0·10) | 0·024 | |
| 3 years, mean (95% CI), n | 36·5 (35·7 to 37·4), 71 | 35·9 (35·0 to 36·7), 79 | −0·67 (−1·32 to −0·03) | 0·041 | |
| 4 years, mean (95% CI), n | 37·1 (36·2 to 38·1), 57 | 36·2 (35·3 to 37·1), 57 | −0·95 (−1·86 to −0·05) | 0·038 | |
| 5 years, mean (95% CI), n | 39·2 (38·0 to 40·4), 29 | 37·8 (36·7 to 39·0), 29 | −1·37 (−2·83 to 0·08) | 0·065 | |
Comparisons are made between groups at each timepoint. At the final follow-up visit the majority of patients had not reached 5 years of study participation, which accounts for the sharp decrease in numbers available for follow-up between year 4 and 5.