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. 2019 Dec 27;15(12):e1008501. doi: 10.1371/journal.pgen.1008501

Fig 4. DIRC3 regulates IGFBP5-dependent gene expression programmes involved in cancer.

Fig 4

(A) DIRC3 depletion induces statistically significant changes (FRD 5%) in the expression of 1886 genes in SK-MEL-28 cells using RNA-seq. (B) RNA-seq of IGFBP5 knockdown SK-MEL-28 cells identifies 557 IGFBP5 target genes (FDR 5%). (C) Intersection of DIRC3- and IGFBP5-regulated genes detects 240 common targets. (D) The expression levels of all DIRC3-IGFBP5 shared target genes change in the same direction following either DIRC3 or IGFBP5 depletion. (E) Gene Ontology enrichment analysis of DIRC3- and IGFBP5 shared target genes was performed using GOstats and FDR correction was applied. Representative significantly enriched categories are shown and the number of genes found in each category are indicated.