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. 2019 Dec 13;15(12):e1008526. doi: 10.1371/journal.pgen.1008526

Table 1. TDP-43 modifying genes with human homologs.

C. elegans gene HUGO symbol BlastP e-value Protein family/ domains
Energy production and metabolism
cox-10 COX10 9E-78 Heme A:farnesyltransferase
F23F12.3 SLC22A5 7E-36 Organic cation/ carnitine transporter
F55G1.5 SLC25A18 9E-68 Mitochondrial glutamate/H+ symporter
paqr-1 ADIPOR1/2 2E-116 Adiponectin receptor
cox-6A COX6A1 2E-14 Cytochrome C oxidase (COX) structural component
Extracellular matrix and cytoskeleton
col-89 COL22A1 1E-12 Fibrillar-associated collagen with interrupted triple helices
gly-8 GALNT11 1E-101 N-Acetylgalactosaminyltransferase
hse-5 GLCE 9E-113 glucuronic acid epimerase
sax-2 FRYL 0E+00 FRY protein
vab-9 TMEM47 2E-12 PMP22/EMP/claudin family
zig-3 HMCN1 1E-09 Immunoglobulin superfamily
Ion transport
cnnm-3 CNNM4 5E-118 Ancient conserved domain
C13B4.1 FRRS1 9E-23 Cytochrome b561 family; ferric chelate reductase
unc-77 NALCN 0E+00 Voltage-gated sodium channel
Nucleic acid function
dna-2 DNA2 2E-129 DNA2/NAM7 helicase
tbx-11 TBR1 2E-28 T-box transcription factor
umps-1 UMPS 1E-100 Uridine monophosphate synthetase
Proteostasis
C47E12.3 EDEM1 0E+00 ER degradation-enhancing alpha-mannosidase
gpx-7 GPX4 1E-39 Glutathione peroxidase
pcp-5 PRCP 1E-114 Prolylcarboxypeptidase
Signaling
F31E3.2 SGK494 5E-59 Serine/ threonine kinase
F40B5.2 TMPPE 1E-67 Metallophosphoesterase
Y44E3A.4 SH3KBP1 1E-31 SH3 domain
Unclassified
T24H10.4 TMEM53 7E-13 DUF829 domain-containing