Table 2. Loss of function mutations in TDP-43 modifier genes.
| C. elegans gene | HUGO symbol | Allele tested | Behavior | TDP-43 protein |
|---|---|---|---|---|
| Energy production and metabolism | ||||
| F55G1.5 | SLC25A18 | gk1250 | NC | NC |
| paqr-1 | ADIPOR1/2 | tm3262 | ++ | ++ |
| Extracellular matrix and cytoskeleton | ||||
| gly-8 | GALNT11 | tm1156 | ++ | ++ |
| hse-5 | GLCE | tm472 | ++ | ++ |
| sax-2 | FRYL | ky216 | ++ | ++ |
| vab-9 | TMEM47 | gk398617 | ++ | NC |
| zig-3 | HMCN1 | tm924 | ++ | ++ |
| Ion transport | ||||
| unc-77 | NALCN | e625 | NC | NC |
| Nucleic acid function | ||||
| tbx-11 | TBR1 | gk681547 | NC | NC |
| umps-1 | UMPS | zu456 | NC | NC |
| Proteostasis | ||||
| gpx-7 | GPX4 | tm2166 | NC | NC |
| pcp-5 | PRCP | gk446 | ++ | NC |
| Signaling | ||||
| F31E3.2 | SGK494 | ok2044 | - - | NC |
| F40B5.2 | TMPPE | gk920502 | NC | NC |
NC = no change; ++ = suppressor; - - = enhancer