Table 2. PD and PAL analyses.
Summary of conventional genotype analyses on the PD and PAL tasks. Summary results were based on simple 2 (genotype) x 4 (stimulus duration) split-plot ANOVA. Impairment or Facilitation was determined by looking for a significant genotype effect or interaction. (3x – 3xTG-AD, 5x – 5xFAD and APP – APP/PS1) mouse lines. Impairment (↓), Improvement (↑) No Effect (-). See also Supplementary file 3, 4, 6, 7.
| Accuracy | Correction Trials | Touch Latency | Reward Latency | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Task | Sex | Age (months) | 3x | 5x | APP | 3x | 5x | APP | 3x | 5x | APP | 3x | 5x | APP | |
| PD | Female | 3-6 | - | - | ↓ | - | ↓ | ↓ | ↓ | ↓ | ↑ | - | ↓ | ↑ | |
| 7-10 | - | ↓ | - | - | ↓ | ↓ | ↓ | ↓ | ↑ | - | ↓ | ↑ | |||
| 11-13 | - | - | - | - | - | - | - | ↓ | ↑ | - | ↓ | - | |||
| Male | 3-6 | ↑ | - | ↓ | ↑ | - | - | - | - | - | - | - | - | ||
| 7-10 | - | - | - | - | - | - | - | - | - | - | ↓ | - | |||
| 11-13 | - | - | - | - | - | - | ↑ | ↓ | - | - | ↓ | - | |||
| PAL | Female | 3-6 | - | - | ↑ | - | ↓ | ↑ | - | - | ↑ | ↑ | ↓ | ↑ | |
| 11-13 | - | - | - | - | ↓ | - | - | ↓ | - | ↑ | ↓ | ↓ | |||
| Male | 3-6 | ↓ | - | ↓ | ↓ | ↓ | ↓ | ↓ | ↑ | ↑ | ↓ | ↓ | - | ||
| 11-13 | - | ↓ | - | - | ↓ | - | - | - | - | ↓ | ↓ | - | |||