Figure 3. Detailed interactions between Slo1 and β4.

(A) Extensive interactions between TM1, TM2 of β4 subunit and transmembrane domains of two contiguous Slo1 subunits (α1 and α2) in stereo. β4 and Slo1 are shown as ribbons and colored blue and red, respectively. Sidechains as well as lipids at the interfaces are shown as sticks and colored according to atom type. (B) β4 and Slo1 interface near the outer leaflet of the membrane in stereo, viewed from the extracellular side. Proteins and lipids are represented and colored as in panel (A). Green spheres represent the K⁺ ions in the selectivity filter. (C) β4 and Slo1 interface near the inner leaflet of the membrane in stereo, viewed from the intracellular side. Proteins and lipids are represented and colored as in panel (A).