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. 2019 Dec 27;9:20200. doi: 10.1038/s41598-019-56639-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Multiple isoforms of TRPA1 are expressed by Anopheles gambiae, Anopheles stephensi, Aedes aegypti and Culex pipiens pallens. (a) Schematic mRNA structures of AgTrpA1A, AgTrpA1D, AsTrpA1A, AsTrpA1C, AaTrpA1A, AaTrpA1B, AaTrpA1C, CpTrpA1A and CpTrpA1C. Each rectangle represents an exon. Black arrows indicate the start point for translation. Exons in the same transcript are connected with grey broken lines. Blue and red boxes are alternatively spliced exons. (b) Amino acid sequence alignments of the N-terminus of AgTRPA1A, AaTRPA1A and AaTRPA1B. The black dot box indicates the previously reported short sequences of AgTRPA1A, AaTRPA1A and AaTRPA1B, which lose 14 amino acids (between 2 red dashed lines) compared with the long TRPA1B sequences. Methionine codons located in this region are highlighted in red. (c) A cartoon summarizes all the mosquito TRPA1 transcripts which are systematically compared in the following experiments. Transcripts with (S) have been reported. Purple asterisks indicate the peptides which were newly recognized in this study. Numbers in circles and boxes indicate the order of exons illustrated in (a).