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. 2019 Dec 27;9:20200. doi: 10.1038/s41598-019-56639-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Addition of 14 amino acids to the N-terminus attenuated channel activity. (a,b) Density comparison of the heat-evoked currents (a) and 5 mM citronellal-evoked currents (b) observed in AgTRPA1A(S) and AgTRPA1A(L) expressed in HEK293 cells, respectively. (c,d) Density comparison of the heat-induced currents (c) and 3 mM citronellal-evoked currents (d) in AaTRPA1A(S) and AaTRPA1A(L) expressed by HEK293 cells, respectively. For (a–d), all values are means ± S.E.M; n ≥ 5; *P < 0.05; **P < 0.01; ***P < 0.001, unpaired Student’s t-test. (e) Comparison of the heat-evoked currents of AgTRPA1A(L) and AgTRPA1A(S) expressed in HEK293 cells with different intracellular concentrations of dissociative 14-amino acid-long peptide. All values are means ± S.E.M; n ≥ 8. No significant difference, one-way ANOVA with Bonferroni’s post hoc analysis.