Table 2.
Metabolic and physiologic parameters 2 weeks after treatment with embryonic stem cell (ESC)- derived extracellular vesicle-mimetic nanovesicles (ESC-NVs).
| Control | STZ-induced diabetic mice | ||
|---|---|---|---|
| HBS | ESC-NVs (1 µg/20 µL) | ||
| Body weight (g) | 30.2 ± 0.3 | 24.5 ± 0.4* | 24.3 ± 0.4* |
| Fasting glucose (mg/dL) | 104.8 ± 6.9 | 232.0 ± 19.6* | 247.0 ± 23.6* |
| Postprandial glucose (mg/dL) | 159.4 ± 5.3 | 535.8 ± 25.7* | 544.6 ± 22.0* |
| MSBP (mm Hg) | 95.1 ± 0.6 | 103.1 ± 1.6 | 99.1 ± 2.2 |
Values are the mean ± SE from N = 5 animals per group. *P < 0.01 vs. control group. STZ, streptozotocin; MSBP, mean systolic blood pressure.