Table 1.
Variable | n | LUNAR1 expression | P | |
---|---|---|---|---|
Increased | Preserved | |||
Total | 196 | 145 | 51 | |
Sex | 0.151* | |||
Male | 124 | 96 | 28 | |
Female | 72 | 49 | 23 | |
Age at diagnosis | 0.312* | |||
≤60 | 145 | 110 | 35 | |
>60 | 51 | 35 | 16 | |
BMI | ||||
Normal weight | 130 | 89 | 41 | 0.030* |
Overweight | 42 | 34 | 8 | |
Obese | 24 | 22 | 2 | |
Tumour location | 0.090* | |||
Right | 66 | 45 | 21 | |
Left | 71 | 59 | 12 | |
Rectum | 59 | 41 | 18 | |
Tumour size | 0.054* | |||
≤3.0 cm | 46 | 29 | 17 | |
>3.0 cm | 150 | 116 | 34 | |
Differentiation status | 0.038* | |||
Well | 42 | 25 | 17 | |
Moderate | 89 | 67 | 22 | |
Poor | 65 | 53 | 12 | |
Depth of invasion | 0.013* | |||
T1 + T2 | 68 | 43 | 25 | |
T3 + T4 | 128 | 102 | 26 | |
Lymph node metastasis | 0.024* | |||
Absent (N0) | 85 | 56 | 29 | |
Present (N1–3) | 111 | 89 | 22 | |
Distant metastasis | 0.161† | |||
Absent (M0) | 174 | 126 | 48 | |
Present (M1) | 22 | 19 | 3 | |
TNM stage | 0.033† | |||
I | 31 | 17 | 14 | |
II | 54 | 39 | 15 | |
III | 89 | 70 | 19 | |
IV | 22 | 19 | 3 | |
MSI | 0.426* | |||
MSS | 168 | 126 | 42 | |
MSI-H | 28 | 19 | 9 | |
KRAS mutation | 0.315* | |||
(−) | 131 | 94 | 37 | |
(+) | 65 | 51 | 14 | |
BRAF mutation | 0192* | |||
(−) | 165 | 125 | 40 | |
(+) | 31 | 20 | 11 | |
PIK3CA mutation | 0.264* | |||
(−) | 160 | 129 | 31 | |
(+) | 36 | 26 | 10 |
*P value when expression levels were compared using Pearson χ2 test.
†P value when expression levels were compared using Fisher’s exact test.