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. 2019 Dec 27;9:20198. doi: 10.1038/s41598-019-55952-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ROC curve for combined biomarker models; 100 cross-validations were performed, and the results were averaged to generate the plot (A). Average of predicted class probabilities of each sample in the 100 cross-validations. Because the algorithm uses a balanced subsampling approach, the classification boundary is located at the center (x = 0.5, dotted line) (B).