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. 2019 Dec 27;9:19946. doi: 10.1038/s41598-019-55703-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differential abundance of species for those clinical variables that significantly affected overall microbial community composition. This heat map shows the log-fold change for the 75 species that were significantly differentially abundant by at least one clinical variable. Some species showed differential abundance by more than one clinical variable, but they are shown grouped by the clinical variable with which they were most significantly associated. Although HIV status significantly affected overall community composition, no species was significantly differentially abundant.