Table 1.

Attenuation of RV and NYVAC-KC vectors in suckling mice.

Age of mice	Construct	Dose(s) tested (log10 ffu/pfu)a	Mortality (%)	LD50 (log10 ffu/pfu)
2–3 days	RV-Gag	5, 6	0	N/A
	RV-gp120TM	5, 6	0	N/A
	RV-Empty	5, 6	0	N/A
	YF17D virus	0 −1 −2 −3	90 71 14 0	−1.13
	NYVAC-KC-gp140	8 7 6	96 87 33	6.3
	VC-2b	2 1 0	67 53 18	0.04

^aSingle dose IC inoculation of suckling CD1 mice; observation for 20 days.

^bwild-type vaccinia strain Copenhagen (VC2).