Table 2.
Genotype and allele distributions of study subjects.
| SNP | Chr. | Gene | Genotype or allele | Derivation sample | Validation sample | ||
|---|---|---|---|---|---|---|---|
| DN cases (n = 246) | Controls (n = 749) | DN cases (n = 179) | Controls (n = 340) | ||||
| rs10963767 | 9 | ADAMTSL1 | TT | 95 (38.62) | 388 (51.80) | 83 (46.37) | 143 (42.06) |
| CT | 112 (45.53) | 296 (39.52) | 82 (45.81) | 169 (49.71) | |||
| CC | 39 (15.85) | 65 (8.68) | 14 (7.82) | 28 (8.24) | |||
| C* | 0.39 | 0.28 | 0.31 | 0.33 | |||
| rs11647932 | 16 | ST3GAL | CC | 145 (58.94) | 538 (71.83) | 116 (64.80) | 253 (74.41) |
| TC | 87 (35.37) | 192 (25.63) | 58 (32.40) | 79 (23.24) | |||
| TT | 14 (5.69) | 19 (2.54) | 5 (2.79) | 8 (2.35) | |||
| T* | 0.23 | 0.15 | 0.19 | 0.14 | |||
| rs11645214 | 16 | SF3B3 | AA | 63 (25.61) | 309 (41.26) | 51 (28.49) | 129 (38.39) |
| GA | 130 (52.85) | 341 (45.53) | 96 (53.63) | 163 (48.51) | |||
| GG | 53 (21.54) | 99 (13.22) | 32 (17.88) | 44 (13.10) | |||
| G* | 0.48 | 0.36 | 0.45 | 0.37 | |||
| rs6499323 | 16 | IL34 | AA | 64 (26.12) | 327 (43.89) | 56 (31.46) | 141 (41.72) |
| GA | 138 (56.33) | 323 (43.36) | 97 (54.49) | 163 (48.22) | |||
| GG | 43 (17.55) | 95 (12.75) | 25 (14.04) | 34 (10.06) | |||
| G* | 0.46 | 0.34 | 0.41 | 0.34 | |||
| rs182784 | 20 | BMP7 | AA | 123 (50.00) | 439 (58.69) | 95 (53.07) | 185 (54.57) |
| GA | 95 (38.62) | 273 (36.50) | 73 (40.78) | 126 (37.17) | |||
| GG | 28 (11.38) | 36 (4.81) | 11 (6.15) | 28 (8.26) | |||
| G* | 0.31 | 0.23 | 0.27 | 0.27 | |||
| rs4811839 | 20 | RAE1 | TT | 109 (44.31) | 420 (56.07) | 81 (45.25) | 179 (52.80) |
| GT | 104 (42.28) | 281 (37.52) | 85 (47.49) | 128 (37.76) | |||
| GG | 33 (13.41) | 48 (6.41) | 13 (7.26) | 32 (9.44) | |||
| G* | 0.35 | 0.25 | 0.31 | 0.28 | |||
| rs6025517 | 20 | RAE1 | TT | 115 (46.75) | 434 (57.94) | 87 (48.60) | 185 (54.73) |
| CT | 103 (41.87) | 273 (36.45) | 80 (44.69) | 123 (36.39) | |||
| CC | 28 (11.38) | 42 (5.61) | 12 (6.70) | 30 (8.88) | |||
| C* | 0.32 | 0.24 | 0.29 | 0.27 | |||
All P > 0.05 from Hardy–Weinberg equilibrium test.
Chr.: chromosome. *Minor allele.