Table 3.
ORs and their 95% CIs for diabetic nephropathy in derivation sample by using the GRS as predictor.
| Variable | Model 1 | Model 2 | Model 3 | |||
|---|---|---|---|---|---|---|
| OR (95% CI) | P-value | OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Gender (ref. women) | 1.11 (0.81, 1.51) | 0.529 | — | — | 1.14 (0.82, 1.57) | 0.432 |
| Age (years) | 1.07 (1.05, 1.09) | <0.01 × 10−12 | — | — | 1.08 (1.06, 1.10) | <0.01 × 10−12 |
| Obesity (ref. BMI<27 kg/m2) | 1.59 (1.14, 2.22) | 0.007 | — | — | 1.61 (1.14, 2.28) | 0.007 |
| Abnormal triglycerides (ref.<150 mg/dL) | 1.63 (1.19, 2.24) | 0.002 | — | — | 1.56 (1.13, 2.17) | 0.008 |
| Hypertension (ref. No) | 2.03 (1.46, 2.81) | 2.26 × 10−5 | — | — | 2.12 (1.51, 2.98) | 1.33 × 10−5 |
| Heart disease (ref. No) | 1.56 (1.08, 2.26) | 0.018 | — | — | 1.48 (1.01, 2.18) | 0.046 |
| GRS (per risk allele) | — | — | 1.22 (1.15, 1.29) | 9.24 × 10−12 | 1.24 (1.17, 1.32) | 1.27 × 10−11 |
Model 1: Clinical risk factors only; model 2: GRS only; model 3: clinical risk factors and GRS.