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. 2019 Dec 27;9:20108. doi: 10.1038/s41598-019-56701-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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KCTD15 up-regulation in MILE study dataset (accession number GEO13159). Microarray data of KCTD15 are plotted as Log2 transformed expression values in Pro B ALL t(11q23)MLL (n = 55 samples, red circles), common/Pre-B-ALL without t (9;22) (n = 232 samples, green triangles), PRE B ALL t(9;22) (n = 111 samples, blue squares) and Healthy bone marrow (n = 72 samples, black triangles). ****p < 0.0001. **p < 0.01(Anova with Tukey’s multiple comparison test). (b) KCTD15 mRNA transcription levels in RS4;11, REH, TOM1 and SEM B-ALL in vitro model systems compared to Peripheral Blood Mononuclear Cells (PBMC). **p-value < 0,01. ***p-value < 0,001 (unpaired t-test). The relative expression was determined using the 2^−ΔCt method. KCTD15 relative expression is shown as mean +/− SD of four technical independent experiments. (c) Western blot of KCTD15 protein levels, in human B-ALL in vitro model systems (RS4;11, REH, TOM-1, SEM) as well as PBMC. Numbers represent the molecular weight of the protein marker expressed in kDa. (d) Cytofluorimetric analyses of KCTD15 protein levels, in human B-ALL RS4;11, REH, TOM-1, and SEM cell lines and PBMC.