Table 2.
List of the top 25 up-regulated genes identified by the RNA-seq analysis.
| Gene ID | Gene symbol | Gene Name | log2FoldChange | pvalue | padj | GOTERM_BP_DIRECT |
|---|---|---|---|---|---|---|
| ENSG00000196549 | MME | membrane metalloendopeptidase(MME) | 6,85828 | 1,96E-53 | 3,20E-49 | GO:0001822~kidney development |
| ENSG00000130508 | PXDN | peroxidasin(PXDN) | 9,497178 | 3,65E-35 | 1,19E-31 | GO:0001960~negative regulation of cytokine-mediated signaling pathway |
| ENSG00000148498 | PARD3 | par-3 family cell polarity regulator(PARD3) | 6,524529 | 1,19E-33 | 3,23E-30 | GO:0006461~protein complex assembly |
| ENSG00000143344 | RGL1 | ral guanine nucleotide dissociation stimulator like 1(RGL1) | 6,807473 | 2,10E-28 | 4,89E-25 | GO:0007264~small GTPase mediated signal transduction |
| ENSG00000143434 | SEMA6C | semaphorin 6C(SEMA6C) | 6,377528 | 2,74E-26 | 5,59E-23 | GO:0001755~neural crest cell migration |
| ENSG00000153885 | KCTD15 | potassium channel tetramerization domain containing 15 | 5,637092093 | 5,67E-22 | 3,74E-19 | GO:0007275 multicellular organism development |
| ENSG00000140848 | CPNE2 | copine 2(CPNE2) | 6,48559 | 4,60E-22 | 6,26E-19 | GO:0071277~cellular response to calcium ion |
| ENSG00000148773 | MKI67 | marker of proliferation Ki-67(MKI67) | 6,602699 | 1,32E-21 | 1,54E-18 | GO:0006259~DNA metabolic process |
| ENSG00000166349 | RAG1 | recombination activating 1(RAG1) | 7,911977 | 1,83E-21 | 1,99E-18 | GO:0002250~adaptive immune response |
| ENSG00000052795 | FNIP2 | folliculin interacting protein 2(FNIP2) | 6,073717 | 3,22E-19 | 2,02E-16 | GO:0000122~negative regulation of transcription from RNA polymerase II promoter |
| ENSG00000122025 | FLT3 | fms related tyrosine kinase 3(FLT3) | 7,383095 | 9,39E-18 | 4,79E-15 | GO:0001776~leukocyte homeostasis |
| ENSG00000120833 | SOCS2 | suppressor of cytokine signaling 2(SOCS2) | 8,196046 | 7,26E-17 | 3,12E-14 | GO:0001558~regulation of cell growth |
| ENSG00000157557 | ETS2 | ETS proto-oncogene 2, transcription factor(ETS2) | 6,456807 | 1,92E-16 | 7,26E-14 | GO:0000122~negative regulation of transcription from RNA polymerase II promoter |
| ENSG00000171105 | INSR | insulin receptor(INSR) | 6,295734 | 6,22E-16 | 2,07E-13 | GO:0000187~activation of MAPK activity |
| ENSG00000065534 | MYLK | myosin light chain kinase(MYLK) | 5,980766 | 4,05E-15 | 1,18E-12 | GO:0006468~protein phosphorylation |
| ENSG00000205336 | ADGRG1 | adhesion G protein-coupled receptor G1(ADGRG1) | 6,192801 | 3,03E-12 | 5,37E-10 | GO:0001525~angiogenesis |
| ENSG00000134531 | EMP1 | epithelial membrane protein 1(EMP1) | 6,015907 | 5,47E-12 | 9,01E-10 | GO:0007275~multicellular organism development |
| ENSG00000273983 | HIST1H3G | histone cluster 1 H3 family member g(HIST1H3G) | 6,045191 | 1,34E-10 | 1,68E-08 | GO:0000183~chromatin silencing at rDNA |
| ENSG00000161940 | BCL6B | B-cell CLL/lymphoma 6B(BCL6B) | 6,588191 | 1,67E-09 | 1.68E-07 | GO:0000122~negative regulation of transcription from RNA polymerase II promoter |
| ENSG00000152192 | POU4F1 | POU class 4 homeobox 1(POU4F1) | 6,015401 | 1,43E-08 | 1.14E-06 | GO:0000122~negative regulation of transcription from RNA polymerase II promoter |
| ENSG00000226674 | TEX41 | testis expressed 41 | 6,094701 | 1,49E-08 | 1.18E-06 | GO: Not assigned |
| ENSG00000189060 | H1F0 | H1 histone family member 0(H1F0) | 7,977572 | 7.86E-07 | 3.69E-05 | GO:0006309~apoptotic DNA fragmentation |
| ENSG00000153531 | ADPRHL1 | ADP-ribosylhydrolase like 1(ADPRHL1) | 7,814898 | 2.86E-06 | 1.09E-04 | GO:0006886~intracellular protein transport |
| ENSG00000131016 | AKAP12 | A-kinase anchoring protein 12(AKAP12) | 7,025709 | 1.19E-04 | 2.346E-03 | GO:0006605~protein targeting |
| ENSG00000166073 | GPR176 | G protein-coupled receptor 176(GPR176) | 6,797679 | 0,000621 | 0,008943 | GO:0007186~G-protein coupled receptor signaling pathway |
For each gene the p-value and the p-value adjusted (p-adj) for multiple testing calculated by the Benjamini and Hochberg’s algorithm are also shown. Genes reported in bold are not associated with leukemias according to DisGeNET database (http://www.disgenet.org/), MEDline database and Genome Web Browser Ensembl.