Table 6.
Multivariable linear regression analyses with changes in serum levels of 10 markers, PSG parameters and biomarker levels.
ΔAHI | ΔMean SaO2 | ΔLSpO2 | ΔCT90% | ΔODI | ΔMAI | ΔESS | ΔGlucose | ΔHOMA-IR | ΔTC | ΔLDL-C | ΔApoB | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
ΔVEGFA | 0.001 | 6.334 | 0.423 | 1.071* | 0.142 | −0.131 | −0.817 | 13.406* | −1.859 | 9.299 | −25 | −52.019 |
ΔAng2 | −0.004 | −0.009 | −0.007 | −0.007* | 0.008* | −0.003 | 0.014 | −0.069* | 0.009 | −0.013 | 0.033 | 0.896* |
ΔE-selectin | 0.02 | 0.23 | −0.41 | −2.649 | 5.112 | −0.008 | 0.319 | 39.159 | −9.695 | −0.886 | −4.8 | 101.277 |
ΔvWF | 1.073 | −11.994 | −3.123 | −5.123 | 0.399 | −0.669 | 2.951 | −9.962 | −9.847 | 45.051 | −4.8 | −260.24 |
ΔvWFCP | −4.076 | −8.073 | −0.41 | −2.649 | 5.112 | −0.008 | 0.319 | 39.159 | −9.695 | −0.886 | −30.332 | 101.277 |
ΔTM | 0.001 | 0.01 | 0.003 | 0.005 | −0.001 | 0 | −0.001 | −0.005 | −0.006 | 0.038 | −0.001 | −0.087 |
Abbreviations: VEGFA = vascular endothelium growth factor A, Ang2 = angiopoietin-2, E-selectin = endothelial-leukocyte adhesion molecule, vWF = von willebrand factor, vWFCP = von willebrand factor cleavage protease, TM = thrombomodulin, AHI = apnea-hypopnea index, SaO2 = oxygen saturation, LSpO2 = lowest pulse oxygen saturation, CT90 = percentage of time during which oxyhemoglobin saturation was < 90%, ODI = oxygen desaturation index, MAI = micro-arousal index, ESS = Epworth Sleepiness Scale, HOMA-IR = homeostasis model of assessment for insulin resistance index, TC = total cholesterol, LDL-C = low-density lipoprotein cholesterol, Apo B = apolipoprotein B.
*p < 0.05.