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. 2019 Dec 27;9:20044. doi: 10.1038/s41598-019-56573-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Bright-field image of a MDCK dome inserted with a pipette (scale bar is 50 μm). (b) MDCK dome injected with fluorescence dye for leaking verification, insets are fluorescence intensity distribution along highlighted lines. (c) Confocal fluorescence image of MDCK dome for illustrating its 3D structure, F-actins are labeled as green, and nuclei are labeled as magenta (scale bar is 20 μm). (d) Pressure inside MDCK domes measured under the influence of different drugs as a function of dome size in terms of radius. (e) Dome size in terms of radius and (f) pressure inside MDCK domes under different drug treatment.