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. 2019 Dec 27;9:20129. doi: 10.1038/s41598-019-56582-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of cross-frequency power coupling between cortex and hippocampus in WT and APP/PS1 mice. (a) Comodulograms showing coupling between different cortical areas and CA1 during occurrence of cortical ripples, after learning session, averaged over 9 WT and 10 APP/PS1 animals. The cross indicates the mean frequency of cortical ripples. (b) Mean correlation coefficient between hippocampal and cortical activity in the cortical ripple frequency band (140–180 Hz). No statistical differences between WT (dark bars) and APP/PS1 group (light bars) were found except higher synchronization between CA1 and PCC in WT compared to APP/PS1 animals (P = 0.014, Wilcoxon rank-sum).