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. 2019 Dec 27;9:19945. doi: 10.1038/s41598-019-56446-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Tissue bioenergetic metabolism can be genetically rewired. (a,b) Laconic FRET maps and quantification of the FRET signal in larval wing discs, in which the expression of the indicated genes has been manipulated at the posterior compartment of the disc with en-Gal4. The upper panel shows the position of the posterior compartment, revealed by anti-En immunostaining. Dotted lines mark the region in which the FRET signal was determined. Data represent the media +/− SD; *p < 0.05 Dunnet’s Test; n ≥ 20 per group. (c) Laconic FRET maps of wing discs where the combined genetic manipulations indicated on each column were carried out at a restricted domain in the anterior/posterior frontier using the ptc-Gal4 driver. Red arrows mark groups of cells with increased lactate levels. The last panel shows the extension of the ptc domain as revealed by ptc > mCherry.