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. 2019 Dec 27;9:20133. doi: 10.1038/s41598-019-56656-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Preservation of modules identified in gene expression profiles of Sham-treated immortalized B cells from childhood asthmatics in gene expression profiles of Sham-treated peripheral mononuclear cell from adult asthmatics. The first (top) panel shows a heatmap of pair-wise correlations among the genes comprising the turquoise, magenta, and purple modules. The second panel shows a heatmap of the edge weights (connections) among the genes comprising the three modules. The third panel shows the distribution of scaled weight degrees (relative connectedness) among the genes comprising the three modules. The fourth panel shows the distribution of node contributions (correlation to module eigengene) among the genes comprising the three modules. Genes are ordered from left to right based on their weighted degree in the discovery cohort, so as to highlight the consistency of the network properties in the replication cohort.