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. 2019 Dec 27;9:19869. doi: 10.1038/s41598-019-56407-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene expression profiles upon Crebl2 knockdown in C2C12 and Hepa1–6 cells. (A,B) Expression profile of C2C12 myoblasts lacking Crebl2. C2C12 cells were treated with control siRNA or siRNA against Crebl2 for 3 days before RNA extraction and RNA-Seq analysis. Expression of each gene is given as counts per million reads (cpm) and compared between control and Crebl2 knockdown (A) and shown as a volcano blot (A’). Genes that are significantly down-regulated (B) or up-regulated (B’) upon Crebl2 knockdown are enriched in secreted proteins, glycoproteins and muscle proteins. (C,D) Expression profile of Hepa1–6 cells lacking Crebl2. Hepa1–6 cells were treated with control siRNA or siRNA against Crebl2 for 3 days before RNA extraction and RNA-Seq analysis. Expression of each gene is given as counts per million reads (cpm) and compared between control and Crebl2 knockdown (C) and shown as volcano plot (C’). Genes that are significantly down-regulated (D) or up-regulated (D’) upon Crebl2 knockdown are enriched in secreted protein and glycoproteins.