Table 3.

Crude Cox regression analysis of survival from the beginning of best supportive care.

Variable	Univariate Analysis			Multivariate Analysis
	HR	95% CI	p-value	HR	95% CI	p-value
Anticancer therapy (none vs. used)	1.40	1.26–1.55	0.0001	1.73	1.27–2.37	0.001
Performance status (0 → 4)	1.70	1.48–1.94	0.0001	1.66	1.44–1.93	0.0001
Disseminated intravascular coagulation (absent vs. present)	4.85	2.72–8.66	0.0001	3.74	2.01–6.96	0.0001
Age (low → high)	0.96	0.95–0.98	0.0001	0.97	0.95–0.98	0.0001
White blood cell (×103) (low → high)	1.05	1.03–1.07	0.0001	1.02	1.01–1.04	0.007
Lactate dehydrogenase (×103) (low → high)	1.01	1.003–1.02	0.007	1.01	1.00–1.02	0.011
Dementia (absent vs. present)	0.61	0.38–0.96	0.034	0.66	0.40–1.08	0.10
Alanine transaminase (low → high)	1.002	1.001–1.004	0.006	1.001	0.999–1.003	0.33
Brain metastasis (absent vs. present)	1.53	1.12–2.09	0.007	0.99	0.72–1.36	0.94
Blood urea nitrogen (low → high)	1.01	0.999–1.02	0.092	0.998	0.99–1.01	0.69
Stage (1 → 4)	1.30	1.14–1.48	0.0001		NI
Hemoglobin (low → high)	0.84	0.79–0.89	0.0001		NI
Albumin (low → high)	0.40	0.32–0.49	0.0001		NI
C-reactive protein (low → high)	1.04	1.03–1.06	0.0001		NI
Patient’s wish about best supportive care (absent vs. present)	0.45	0.32–0.62	0.0001		NI
Doctor’s decision about best supportive care (absent vs. present)	2.13	1.48–3.09	0.0001		NI
Transfer to hospice or home (absent vs. present)	0.44	0.37–0.53	0.0001		NI
Liver dysfunction (absent vs. present)	1.46	0.96–2.21	0.074		NI

Abbreviations: HR, Hazard ratio; C.I., confidence interval; Variables with a p-value < 0.10 on univariate analysis were entered into multivariate Cox analysis using.

the simultaneous method. NI, not included in the best multivariate Cox regression model.