Table 4.
Propensity score adjusted Cox regression analysis of survival from the beginning of best supportive care.
| Variable | Univariate analysis | Multivariate Analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-value | HR | 95% CI | p-value | |
| Age (low → high) | 0.96 | 0.95–0.98 | 0.0001 | 0.97 | 0.95–0.98 | 0.0001 |
| Performance status (0 → 4) | 1.62 | 1.40–1.88 | 0.0001 | 1.54 | 1.31–1.82 | 0.0001 |
| Disseminated intravascular coagulation (absent vs. present) | 4.38 | 2.40–8.00 | 0.0001 | 3.35 | 1.75–6.39 | 0.0001 |
| Anticancer therapy (none vs. used) | 2.07 | 1.51–2.84 | 0.0001 | 1.62 | 1.17–2.24 | 0.001 |
| White blood cell (×103) (low → high) | 1.06 | 1.04–1.08 | 0.0001 | 1.03 | 1.01–1.05 | 0.002 |
| Lactate dehydrogenase (×103) (low → high) | 1.01 | 1.001–1.02 | 0.025 | 1.01 | 1.002–1.02 | 0.015 |
| Dementia (absent vs. present) | 0.53 | 0.33–0.85 | 0.008 | 0.65 | 0.40–1.08 | 0.09 |
| Alanine aminotransferase (low → high) | 1.002 | 1.001–1.004 | 0.008 | 1.001 | 0.999–1.003 | 0.38 |
| M factor (0 → 1) | 1.33 | 0.99–1.78 | 0.061 | 1.09 | 0.77–1.55 | 0.62 |
| T factor (1 → 4) | 1.16 | 1.06–1.27 | 0.001 | 1.02 | 0.93–1.12 | 0.67 |
| Hemoglobin (low → high) | 0.87 | 0.82–0.93 | 0.0001 | NI | ||
| Albumin (low → high) | 0.42 | 0.33–0.53 | 0.0001 | NI | ||
| C-reactive protein (low → high) | 1.03 | 1.02–1.05 | 0.0001 | NI | ||
| Doctor’s decision about best supportive care (absent vs. present) | 0.03 | 0.006–0.18 | 0.0001 | NI | ||
| Stage (1 → 4) | 1.25 | 1.10–1.43 | 0.001 | NI | ||
| Number of chemotherapy courses (0 → 9) | 1.08 | 1.01–1.16 | 0.018 | NI | ||
| Aspartic acid aminotransferase (low → high) | 1.001 | 1.000–1.002 | 0.018 | NI | ||
| N factor (0 → 3) | 1.13 | 0.995–1.28 | 0.060 | NI | ||
Abbreviations: HR, Hazard ratio; C.I., confidence interval; Variables with a p-value < 0.10 on univariate analysis were entered into the multivariate Cox analysis.
using a simultaneous method. NI, not included in the best multivariate Cox regression model.