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. 2019 Dec 27;9:20183. doi: 10.1038/s41598-019-56366-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Sorting of LSEC subtypes by flow cytometry. Gating strategy for analyses and sorting of primary isolated LSEC. (A) Viable cells within the analyzed sample. (B) Single cells. Aggregates and doublets are excluded (C) CD11b/c-positive Kuppffer cells are excluded. (D) LSEC phenotypes: CD32b⁺ (specialized/differentiated) and CD32b⁻ (capillarized/dedifferentiated). (E) Percentage of CD32b⁻ cells indentified in control diet (CD-Veh, n = 4) and HFGFD rats after vehicle (HFGFD-Veh, n = 4), simvastatin (HFGFD-Sim, n = 4) or atorvastatin (HFGFD-Ato, n = 4) treatment. Group values are expressed as mean ± SEM. Percentage of each individual is shown as a dot. *p < 0.05; **p < 0.01 compared to HFGFD-vehicle (ANOVA).