Table 1.
Hemodynamic measurements.
| CD | HFGFD | HFGFD | HFGFD | |
|---|---|---|---|---|
| Vehicle | Vehicle | Simvastatin | Atorvastatin | |
|
MAP (mmHg) |
108.85 ± 4.86 | 109.88 ± 3.84 | 105.29 ± 7.26 | 108.76 ± 5.90 |
|
SMABF (mL/[min·100 g]) |
3.86 ± 0.58 | 3.36 ± 0.49 | 3.10 ± 0.46 | 3.34 ± 0.37 |
|
SMAR (mmHg/mL·min·100 g) |
31.98 ± 4.27 | 36.46 ± 4.79 | 35.52 ± 2.92 | 36.37 ± 3.11 |
|
PP (mmHg) |
8.30 ± 0.22*** | 10.47 ± 0.37 | 9.29 ± 0.25** | 8.85 ± 0.30*** |
|
PBF (mL/[min·100 g]) |
2.56 ± 0.15 | 2.89 ± 0.22 | 3.00 ± 0.35 | 2.81 ± 0.24 |
|
IHVR (mmHg/mL·min·100 g) |
3.38 ± 0.27 | 3.62 ± 0.34 | 3.42 ± 0.46 | 3.17 ± 0.31 |
|
Heart rate (BPM) |
328.03 ± 7.14 | 322.71 ± 10.09 | 325.06 ± 8.60 | 324.51 ± 9.30 |
Values are expressed as mean ± SEM in CD-Vehicle (n = 15), HFGFD-Vehicle (n = 15), HFGFD-Simvastatin (n = 12) and HFGFD-Atorvastatin (n = 14). MAP, mean arterial pressure; SMABF, superior mesenteric artery blood flow; SMAR, superior mesenteric artery resistance; PP, portal pressure; PBF, portal blood flow; IHVR, intrahepatic vascular resistance; BPM, beats per minute. *p < 0.05, **p < 0.01, ***p < 0.001 compared to HFGFD-vehicle (ANOVA).