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. 2019 Dec 27;9:19999. doi: 10.1038/s41598-019-56593-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Target prediction. (a) mRNA target prediction of miR-16-5p and its isomiR 5 from Supplementary Table S1. The canonical miRNA and isomiR sequences are shown at the bottom with the seed in red and the nucleotide substitution in blue. (b) mRNA target prediction of miR-126-3p and its isomiR 1 from Supplementary Table S1 (c) mRNA target prediction of miR-142-3p and its isomiR 2 from Supplementary Table S1. The canonical and isomiR sequences are shown at the bottom with the seed in red and addition of a nucleotide at the 3′-end in blue. Numbers are the total number of mRNA targets predicted by each of the databases.