. 2019 Dec 27;9:19889. doi: 10.1038/s41598-019-56496-7

Table 3.

Novel elite athletes-associated mQTLSs reflecting gene/environment (exercise) interaction.

SNP	Gene	Metabolite	Functional relationship between gene and metabolite	Interaction with athletic performance (exercise)
rs55729124	FOLH1	N-Acetylaspartylglutamic acid (NAAG)	Gene encodes an enzyme that directly cleaves NAAG into NAA + Glutamate	Aerobic fitness was reported to enhance NAA levels, leading to increased cognitive enhancement³³
rs3798793	VNN1	Linoleoyl ethanolamide	Gene encodes a membrane protein that participates in hematopoietic cell trafficking	Exercise increases serum concentrations of endocannabinoids including linoleoyl ethanolamide³⁶
rs17101394	SGPP1	Ceramide	Gene encodes enzyme that directly mediates recycling of sphinogsine into cermides	Acute prolonged exercise was shown to influence ceramide metabolism in human skeletal muscle⁴²