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. 2019 Dec 27;9:20056. doi: 10.1038/s41598-019-56302-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cell migration and fibrosis are significantly inhibited by ICG-001 and C-82. (A) Scratch assay for 24 hours. Representative photos at 0 and 24 hours are shown. The control became confluent after 24 hours. (B) The analysis of the reduction of the ratio of the scratched area (cell migration ratio) at 24 hours. The data are shown as relative values at 24 hours against the scratched area of the controls at 0 hours. ICG-001 and C-82 inhibited cell migration significantly compared with controls. n = 5. *p < 0.05, Student’s t-test. (C) Representative result of a collagen gel contraction assay in ECSC. The concentrations of ICG-001 and C-82 were 20 μM and 2 μM, respectively. (D) Collagen gel contraction was significantly inhibited by ICG-001 and C-82. n = 3. *p < 0.001, **p < 0.01, Student’s t-test. Error bars represent standard deviation (SD).