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. 2019 Dec 27;9:19864. doi: 10.1038/s41598-019-56462-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AAV8-HLA-G1/5 Improves EAU histology scores. (a) Representative images of ocular histology demonstrate iris thickening and severe inflammatory cell infiltration in the ciliary body, iris, anterior chamber and vitreous body, as well as moderate vasculitis formation in experimental autoimmune uveitis (EAU) untreated eyes (C,D). Mild infiltration of inflammatory cells was observed in the vitreous and retina in topical dexamethasone and HLA-G1/5 treated EAU eyes (E&F, G&H, respectively). Control healthy eyes (A&B). (hematoxylin & eosin staining, original magnification: 20x and 40x). The histological infiltrative scores (b) and structural scores (c) were significantly decreased in the scAAV8-HLA-G1/5 treated (n = 4 eyes) and dexamethasone (dex) treated EAU eyes (n = 4 eyes) as compared to the non-treated EAU eyes (n = 4 eyes) (p = 0.01, p = 0.02; Wilcoxon test). There was no significant difference between healthy eyes (n = 2 eyes) and either EAU treatment group. Each point is the average score of an individual eye of two blinded observers and mean scores of each treatment group are denoted by the horizontal bars.