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. 2019 Dec 27;9:20257. doi: 10.1038/s41598-019-56208-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Model of c-Cbl mediated PD-1 regulation. c-Cbl in immune cells (such as macrophages) binds and ubiquitinates PD-1 to target it for proteasomal degradation. This results in downregulation of surface expression of PD-1, which in macrophages augments the tumor cell phagocytosis resulting in suppression of tumor growth.