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. 2019 Dec 27;9:19844. doi: 10.1038/s41598-019-56230-3

Table 2.

Individual SNP analysis of AAA associated SNPs reported by GWAS and the association results for diameter of the aneurysm sac (in millimeters).

Reported by literature This study
SNP Chr BP Near(est) gene(s) Alleles EAF β a p EAF β SE p
rs602633 1 109821511 PSRC1- CELSR2-SORT1 T* - G 0.199 −0.129

6.58

x10−9

 0.208 −2.017 1.238 0.104
rs4129267 1 154426264 IL6R T* - C 0.370 −0.132

4.76

x10−13

 0.355 1.422 1.073 0.186
rs1795061 1 214409280 SMYD2 T* - C 0.337 0.123

8.80

x10−11

 0.307 0.490 1.054 0.642
rs10757274 9 22096055 CDKN2BAS1/ANRIL A* - G 0.462 −0.216

1.54

x10−33

 0.504 0.319 1.264 0.752
rs10985349 9 124425243 DAB2IP T* - C 0.195 0.158

2.40

x10−11

 0.200 −0.445 1.009 0.725
rs1466535 12 57534470 LRP1 G* - A 0.679 0.199b

9.99

X10−7

 0.655 2.554 1.022 0.013
rs9316871 13 22861921 LINC00540 A* - G 0.201 −0.136

4.75

x10−10

 0.796 0.675 1.272 0.596
rs6511720 19 11202306 LDLR T* - G 0.096 −0.218

7.90

x10−14

 0.094 2.612 1.755 0.138
rs3827066 20 44586023 PCIF1-ZNF335-MMP9 T* - C 0.179 0.201

2.13

x10−17

 0.167 −0.900 1.323 0.496
rs2836411 21 39819830 ERG T* - C 0.369 0.107

5.80

x10−9

 0.362 0.499 1.238 0.687

Abbreviations: SNP = single nucleotide polymorphism, AAA = abdominal aortic aneurysm, Chr = chromosome, BP = base pair, EAF = effect allele frequency, β = beta-coefficient, SE = standard error.

*Effect allele, aβ converted from combined odds ratio’s (discovery and validation phase) of summary statistics of Jones et al.12, bβ converted from discovery phase of summary statistics of Bown et al.7.