Table 1.
Univariable and multivariable analyses for determining factors correlated to PDC establishment.
| Variate | PDC establishment | Pa | OR (95% CI) | |
|---|---|---|---|---|
| No (n = 73) | Yes (n = 23) | |||
| Univariate analysis | ||||
| Age | 57 (19–88) | 57 (19–77) | 0.6031b | |
| Gender | 0.7585 (0.2647–2.1520) | |||
| Female | 40 (78.4%) | 11 (21.6%) | 0.6352 | |
| Male | 33 (73.3%) | 12 (26.7%) | ||
| Prior therapy | 0.3005 (0.0206–4.3759) | |||
| Yes | 71 (77.2%) | 21 (22.8%) | 0.2417 | |
| No | 2 (50.0%) | 2 (50.0%) | ||
| Prior chemotherapy | 0.4745 (0.1626–1.3841) | |||
| Yes | 51 (81.0%) | 12 (19.0%) | 0.1367 | |
| No | 22 (66.7%) | 11 (33.3%) | ||
| Prior TKI therapy | 1.0289 (0.2727–4.8489) | |||
| Yes | 60 (75.9%) | 19 (24.1%) | 1 | |
| No | 13 (76.5%) | 4 (23.5%) | ||
| EGFR mutation | 0.5904 (0.1994–1.8049) | |||
| Yes | 53 (79.1%) | 14 (20.9%) | 0.3064 | |
| No | 20 (69.0%) | 9 (31.0%) | ||
| ALK fusion | 0.9455 (0.1524–4.1794) | |||
| Yes | 10 (76.9%) | 3 (23.1%) | 1 | |
| No | 63 (75.9%) | 20 (24.1%) | ||
| ROS1 fusion | 3.0575 (0.6588–13.6332) | |||
| Yes | 6 (54.5%) | 5 (45.5%) | 0.1259 | |
| No | 67 (78.8%) | 18 (21.2%) | ||
| Source | 1.9584 (0.2184–94.6450) | |||
| Pleural effusion | 67 (75.3%) | 22 (24.7%) | 1 | |
| Others | 6 (85.7%) | 1 (14.3%) | ||
| Time to processing | 1.9584 (0.2184–94.6450) | |||
| <4 hours | 67 (75.3%) | 22 (24.7%) | 1 | |
| >24 hours | 6 (85.7%) | 1 (14.3%) | ||
| Sample volume | 200 (10–1350) | 200 (60–500) | 0.58232b | |
| Cytology | 8.3654 (2.1991–47.7354) | |||
| Malignancy | 32 (61.5%) | 20 (38.5%) | <0.001 | |
| Others | 41 (93.2%) | 3 (6.8%) | ||
| Tumor colony formation | 22.0772 (3.2262–953.2819) | |||
| Yes | 36 (62.1%) | 22 (37.9%) | <0.001 | |
| No | 37 (97.4%) | 1 (2.6%) | ||
| Multivariate analysisc | ||||
| Variate | P | OR (95% CI) | ||
| Malignancy vs others | 0.0239 | 4.8336 (1.2322–18.9608) | ||
| Tumor colony formation vs no colony formation | 0.0131 | 14.1733 (1.7469–114.9934) | ||
aThe P value is calculated using the Fisher’s exact test unless indicated otherwise.
bThe P value is calculated with the Mann-Whitney U test.
cThe P value and odd ratio are analyzed by multivariate logistic regression.
PDC, patient-derived cells.