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. 2019 Dec 27;9:19832. doi: 10.1038/s41598-019-55301-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hemodynamic evaluation of pulmonary arterial hypertension with statin treatment in a NHP model of HIV-PAH. (a) Study schematic of statin treatment, SIV infection, and serial right heart catheterization (RHC). (b) Mean arterial pressure (mPAP), comparing treatment cohorts at baseline (BL), 6 months post-infection (6mpi), and terminal timepoints (10–12mpi). (c) mPAP is calculated from (d) right ventricular systolic pressure (RVSP), where $m P A P (i n m m H g) = 0.65 \times (R V S P) + 0.55$ . PAH is defined as mPAP ≥ 25 mmHg as indicated by the dashed lines. (b–d) Serial and group characterizations of hemodynamics were analyzed using repeated measures mixed modeling. Data represents the mean ± SD.