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. 2019 Dec 27;9:19832. doi: 10.1038/s41598-019-55301-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of statins on SIV-PAH-associated cytokine profiles. (a) Bronchoalveolar lavage fluid (BALF) TGF-β levels at 6mpi. (b,c) Terminal plasma levels of MIP-1α and TNF-α, respectively. (d) Plasma IL-15 levels at 6mpi. (a–d) Mann-Whitney U test was used for statistical analysis. Data represents the mean ± SD. (e) Spearman correlation analysis between mPAP and plasma IL-15 at 6mpi in SIV/Untreated animals (left), and statin-treated cohorts (center, right); R, Spearman coefficient.