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. 2019 Dec 27;9:19832. doi: 10.1038/s41598-019-55301-9

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of statins on SIV-associated fibrosis in the heart and pulmonary arteries. (a) Quantification of right ventricle (RV) collagen deposition quantified from Masson’s trichrome-stained heart sections. (b) Correlation analysis between peak mPAP and RV fibrosis (%RV Collagen/170 mm²) in SIV/Untreated animals (left), and statin-treated cohorts (center, right). (c) Representative images of Masson’s trichrome-stained right ventricle sections. (d) Quantification of pulmonary periarteriolar collagen deposition quantified from Picro-Sirius Red-stained lung sections. (e) Correlation analysis between peak mPAP and periarteriolar fibrosis (%Area threshold) in SIV/Untreated animals (left), and statin-treated cohorts (center, right). (a,d) Mann-Whitney U test was used for statistical analysis. Data represents the mean ± SD. (b,e) Spearman correlation analysis; R, Spearman coefficient.