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. 2019 Dec 27;9:20021. doi: 10.1038/s41598-019-56277-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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ONECUT2 is aberrantly expressed in lung cancer. (A) ONECUT2 expression in various lung cancer subtypes from dataset GSE30219. Data are presented as a Tukey box plot. SQCC: squamous cell carcinoma. (B) Scatter plot of ASCL1 and ONECUT2 expression of SCLC samples from GSE30219. (C) Scatter plot of ASCL1 and ONECUT2 expression of LCNEC samples from GSE30219. (D) Dot plot of Onecut2 and Ascl1 expression in wide type (WT) and Rb1/Trp53 double knockout (Rb1/Trp53 DKO) mice from dataset GSE18534. Error bars indicate mean ± SD. (E) Dot plot of ONECUT2 expression of 58 ADC samples and paired normal tissues from TCGA (****p < 0.0001, paired t-test). (F) Scatter plot of ASCL1 and ONECUT2 expression of ADC samples from GSE30219. (G) Overall survival analysis of ADC patients from TCGA-LUAD stratified by the upper quantile expression level of ONECUT2. (H,I) Overall survival analysis of RAS-driven (H) ADC patients or patients with oncogenic alterations in RTK/RAS/BRAF pathway (I) in the presence of TP53 loss of function alterations from TCGA-LUAD stratified by upper quantile expression level of ONECUT2.