Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 27;9:20021. doi: 10.1038/s41598-019-56277-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

ONECUT2 binds and modulates the activity of bivalent chromatin. (A) Homer motif analysis of high confidence ONECUT2 peaks. (B) GREAT analysis of high confidence ONECUT2 peaks shows distribution of gene-region assignments around TSS. (C) Percentage plot of Roadmap A549 cell chromatin states around activated and repressed ONECUT2 target gene TSS, as well as summits of activating and repressive peaks. Chromatin state around the TSSs of all protein-coding genes and all ONECUT2 target genes are shown as control. (D,E) Plot of average H3K4me3 (D) and H3K27me3 (E) log₂ fold change by ChIP-Seq (A549-ONECUT2 versus ΔDBD) around activating and repressive ONECUT2 peaks. (F,G) Plot of average H3K4me3 (F) and H3K27me3 (G) log₂ fold change by ChIP-Seq (A549-ONECUT2 versus ΔDBD) around TSS of genes associated with activating and repressive ONECUT2 peaks. (K) Representative illustration of H3K4me3 and H3K27me3 signals around four selected loci alongside ONECUT2 binding signals in A549-ONECUT2 cells.