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Increase in dark levels of Ca2+ and cGMP according to numerical simulations of a mouse rod outer segment compared to a wild-type case.
| GCAP1WT/E111Va | GCAP1E111V/E111V | 3XGCAP1WT/GCAP1E111V + GCAP2 | 3XGCAP1WT/GCAP1E111V-GCAP2 | |
|---|---|---|---|---|
| X-fold [Ca2+free] | 3.1 | 12.5 | 1.4 | 3.0 |
| X-fold [cGMP] | 1.4 | 2.0 | 1.1 | 1.4 |
acombination of individual weight factor fi to simulate each condition are illustrated in the Methods.
