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. Author manuscript; available in PMC: 2019 Dec 28.
Published in final edited form as: Biochim Biophys Acta Gen Subj. 2018 May 28;1862(11):2518–2527. doi: 10.1016/j.bbagen.2018.05.018

Fig. 5.

Fig. 5.

Gene Expression Suggesting Halting of H2AX/Bcl-2 Apoptosis in Psoriatic Lesions.

Significant upregulation of H2A histone family member X (H2AX), proapoptotic B-cell lymphoma 2 (Bcl-2), Bcl-2-like protein 4 (BAX), Bcl-2 homologous antagonist/killer (BAK), and Bcl-2 ovarian killer (BOK) suggesting apoptosis likely halted by significant downregulation of MIR24–2, an essential mediator of H2AX/Bcl-2 apoptotic pathway. Data from GEO data set GDS4602 comparing healthy patients (n = 64) to Psoriasis Patients with samples from nonlesional healthy skin (n = 58) and psoriatic skin (n = 58). Statistical Analysis: nonparametric Kruskall-Wallis test with bars indicating median raw values, ± interquartile range. **** and #### indicating p < 0.0001; *** or ### p < 0.001, * or # p < 0.05 and ns as p > 0.05.