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. Author manuscript; available in PMC: 2019 Dec 28.
Published in final edited form as: Biochim Biophys Acta Gen Subj. 2018 May 28;1862(11):2518–2527. doi: 10.1016/j.bbagen.2018.05.018

Fig. 6.

Fig. 6.

Gene Expression Suggesting Increase in Intracellular Iron in Psoriatic Lesions.

Significant changes in gene expression of transferrins (TFRC or TFR1) and TFR2, metal regulatory transcription factor 1 (MTF1), specificity protein 1 (SP-1), glutaredoxin 3(GRX3), and ceruloplasmin (CP), involved cellular iron sensing suggest increases in intracellular iron in psoriatic skin. Data from GEO data set GDS4602 comparing healthy patients (n = 64) to Psoriasis Patients with samples from nonlesional healthy skin (n = 58) and psoriatic skin (n = 58). Statistical Analysis: Normal distribution, ANOVA test with bars indicating mean raw values, ± SEM. or nonparametric Kruskall-Wallis test with bars indicating median raw values, ± interquartile range. **** and #### indicating p < 0.0001; *** or ### p < 0.001, * or # p < 0.05 and ns as p > 0.05.