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. Author manuscript; available in PMC: 2019 Dec 28.
Published in final edited form as: Biochim Biophys Acta Gen Subj. 2018 May 28;1862(11):2518–2527. doi: 10.1016/j.bbagen.2018.05.018

Fig. 7.

Fig. 7.

Gene Expression in Psoriatic Skin lesions mirror Erastin-like System XC inhibition.

Psoriatic lesions show gene expression pattern similar to erastin-like System XC inihibition. SLC7A11 and SLC3A2, were upregulated as compensatory response to similar erastin. Significant upregulation of Activating transcription factor 4 (ATF4), and ChaC Glutathione Specific Gamma-Glutamylcyclotransferase 1 (CHAC1) was also in agreement with an erastin-liked induced inhibition of System XC, the mechanism of erastin-mediated ferroptosis. Data from GEO data set GDS4602 comparing healthy patients (n = 64) to Psoriasis Patients with samples from nonlesional healthy skin (n = 58) and psoriatic skin (n = 58). Statistical Analysis: nonparametric Kruskall-Wallis test with bars indicating median raw values, ± interquartile range. ± SEM. **** and #### indicating p < 0.0001; *** or ### p < 0.001, * or # p < 0.05 and ns as p > 0.05.