Skip to main content
. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Transl Stroke Res. 2019 Jun 28;11(2):254–266. doi: 10.1007/s12975-019-00712-z

Figure 4. Inhibition of CaN or GSK3β reverses TRPM2-mediated LTP deficits.

Figure 4.

A) Experimental timeline. B) Time course of fEPSP slope from MALE sham control mice (black), 7 days after CA/CPR (open black circles), 7 days after CA/CPR slices treated 1 μM cyclosporine (blue) or 10 μM FK-506 (red) for 1 hour prior to recording (blue) and sham control mice 7 days after 20 mg/kg tatM2NX (green). C) Quantification of change in fEPSP slope 60 minutes after TBS stimulation normalized to 20 minutes of baseline recording. D) Time course of fEPSP slope from male sham control mice (black), 7 days after CA/CPR (open black circles), 7 days after CA/CPR slices treated 1 μM CT99021 (blue) or 1 μM Tidegulib (red) for 1 hour prior to recording (blue) and sham control mice 7 days after 20 mg/kg tatM2NX (green). E) Quantification of change in fEPSP slope 60 minutes after TBS stimulation normalized to 20 minutes of baseline recording.