Table 4.

GTP release profiles with various models at different loading concentrations of GTP and at different conditions

Condition	Zero order		First order		Higuchi model		Hixson- Crowell model		Korsmeyer- Peppas model		Drug transport mechanism
	R²	k₀	R²	k 1	R²	k H	R²	k HC	R²	n
1 mg/mL GTP	0.9901	0.501	0.7792	0.019	0.8106	5.49	0.898	0.002	0.859	0.641	Anomalous
2.5 mg/mL GTP	0.9807	0.892	0.9879	0.023	0.7529	9.78	0.9922	0.002	0.8395	0.438	Fickian
5 mg/mL GTP	0.9964	1.321	0.9829	0.015	0.7699	17.7	0.9936	0.053	0.8548	0.548	Anomalous
10 mg/mL GTP	0.9970	1.717	0.9577	0.011	0.7868	26.1	0.9842	0.001	0.8613	0.573	Anomalous
pH 3	0.9794	0.730	0.9537	0.018	0.8432	9.80	0.9649	0.059	0.8483	0.674	Anomalous
pH 7.4	0.9964	1.321	0.9829	0.015	0.7699	17.7	0.9936	0.053	0.8548	0.548	Anomalous
pH 9	0.9956	1.52	0.9534	0.014	0.7912	20.3	0.9779	0.051	0.8616	0.636	Anomalous
RT	0.9912	1.21	0.9407	0.010	0.8385	18.8	0.9634	0.038	0.8844	0.647	Anomalous
37 °C	0.9964	1.321	0.9829	0.015	0.7699	17.7	0.9936	0.053	0.8548	0.548	Anomalous
45 °C	0.9947	1.286	0.8589	0.010	0.8208	19.9	0.9320	0.037	0.8695	0.711	Anomalous