Table 2.
Effect of pretreatment of rats with Compounds 1 – 10b, celecoxib or indomethacin on the carrageenan-induced paw edema and formalin test
| Compound | Change in paw volume a (cm 3 ) Mean ± SEM | AUC of pain score b Mean ± SEM |
|---|---|---|
| Control (DMSO) | 0.37 ± 0.02 | 86.46 ± 4.79 |
| 1b | 0.21 ± 0.06 * | 72.08 ± 5.23 |
| 2b | 0.39 ± 0.02 | 48.75 ± 9.95 * |
| 3b | 0.26 ± 0.01 * | 62.04 ± 12.95 |
| 4b | 0.30 ± 0.05 | 83.28 ± 14.76 |
| 5b | 0.34 ± 0.06 | 57.03 ± 12.39 |
| 6b | 0.21 ± 0.05 * | 61.70 ± 4.26 |
| 7b | 0.29 ± 0.03 | 72.00 ± 12.65 |
| 8b | 0.48 ± 0.04 | 96.10 ± 7.40 |
| 9b | 0.29 ± 0.04 | 76.38 ± 11.03 |
| 10b | 0.46 ± 0.06 | 86.73 ± 8.73 |
| Celecoxib | 0.05 ± 0.02 *** | 62.61 ± 4.71 |
| Indomethacin | 0.22 ± 0.05 * | ND |
aPaw volume was measured before and 4 h after carrageenan injection into rat hind paw and the change in paw volume was calculated for each rat. Data were shown as mean ± SEM (N = 6-8 in each group).
b AUC of pain scores during 60 min of observation in formalin test. Data were shown as mean ± SEM (N = 6-8 in each group).
*p < 0.05 significant difference compared with the control group. ND Not determined.