Fig. 4.

Cardiotoxic effects of cancer therapies. Although a number of targeted and untargeted cancer therapies have shown efficacy in cancer treatment, these therapies also cause cardiotoxic effects that can result in profound cardiovascular complications. Chemotherapies, including anthracyclines such as doxorubicin, tyrosine kinase inhibitors, Her2-targeted therapies, and proteosome inhibitors, are associated with vascular dysfunction and CM damage that can lead to heart failure. Platinum-based therapies, microtubule inhibitors, and radiation therapy have also been linked to arrhythmias and pericardial disease. The pathobiology or the disease mechanisms of such cardiotoxic effects of various cancer therapies have not been elucidated and must be addressed in a patient-specific manner.