Figure 2.

PLA2R-AB can significantly elevate over weeks to months prior to MN diagnosis. Rapid appearance of prediagnostic PLA2R-AB. Autoantibody analysis identified five patients with PLA2R-AB–positive MN that demonstrated a rapid rise from seronegative to significantly elevated in <1 year. The PLA2R-AB levels in LU derived from serial samples of the seropositive cases are plotted on the y axis using a log10 scale. The cut-off value for determining PLA2R-AB seropositivity is shown by the dotted line. Time zero represents biopsy-proven diagnosis of MN.